SetPoint Medical is dedicated to treating patients with debilitating inflammatory diseases, such as Crohn's Disease and rheumatoid arthritis, using proprietary implantable neuromodulation devices.

The scientific platform is based on the Inflammatory Reflex—the natural mechanism by which the central nervous system regulates the immune system. This mechanism was discovered by SetPoint co-founder Kevin Tracey and published in Nature in May 2000. Since then, the Inflammatory Reflex has been characterized in more than 100 peer reviewed papers in leading scientific journals. Anti-inflammatory potency comparable to leading drugs has been demonstrated in multiple animal models. The company is currently conducting human trials in rheumatoid arthritis at four European centers.

Fibromyalgia, a common chronic pain condition, affects more than 5 million people in the United States. A poorly understood disorder, Fibromyalgia has been under diagnosed and under treated, but is thought to be the result of overactive nerves. Recent research also suggests that changes in the central nervous system (brain, spinal cord, and nerves) may be responsible. Fibromyalgia is characterized by widespread pain and tenderness, and is frequently associated with nervousness, irritability, anxiety, fatigue, depression, and insomnia. In addition symptoms may appear as chemical sensitivities, allergies, Restless Leg Syndrome, cold or burning hands and feet, and Irritable Bowel Syndrome.

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