Renarthro - Smarter Choice than Glucosamine and Chondroitin

The study observed that participants who had applied an ointment containing frankincense extract to the affected joint experienced an improvement of about seventy per cent in their knee’s mobility, and a fifty to sixty per cent reduction in knee joint inflammation. At the same time, the incidence of joint swelling was considerably decreased.  A number of participants declared the results as appearing faster and being more effective than when using ibuprofen and other common chemical-based anti-inflammatory treatment options.

Another study, completed a year ago at the Institute of Pharmacology at the University of Tubingen in Germany, identified myrrh (commiphora molmol) extract exhibiting considerable anti-inflammatory and analgesic properties whenever it was applied locally to acute and chronic inflamed joints in individuals suffering from rheumatoid arthritis. The German study discovered that the myrrh extract considerably decreased swelling in the hands and legs. 

Renarthro is unique formulation of extracts from frankincense,  myrrh and  whey

This combination of frankincense and myrrh extracts with special extract of whey protein is completely unique product and patent-protected. Farmavita Ltd's patent-protected innovation lies in the fact that Renarthro's efficacy is not a mere sum of the respective effects of the individual components, but rather a synergy of each ingredients' effects.

Why to take Renarthro instead of outdated products based on glucosamine and chondroitin?

• The new and unique synergistic combination of frankincense, myrrh and a bioactive milk protein.
• Provides relief from inflammation and alleviated pain fast, within only a few days, when compared to 30 - 60 days needed for glucosamine.
• Quickly acheived improvement in mobility and range of movement.
• Safer – Renarthro contains ingredients that are hypoallergenically proven, compared to shellfish based glucosamine products with high iodine content.
• Green and Sustainable - Renarthro uses ingredients collected without any harm done to plants or animals , compared to chondroitin obtained from cartilage of sea sharks, an endangered animal.

Renarthro^® has quickly become a market leader among locally manufactured brands, in spite of a humble marketing budget. In fact, the best form of marketing has been word-of-mouth coming from satisfied customers. 

The Renarthro^® product line includes Renarthro capsules, Renarthro Ice-Gel and Renarthro Honey. They are available for online purchase through Amazon.com, Amazon.de and Amazon.co.uk.

In order to develop products Farmavita d.o.o. made extensive scientific research. Here are some reference quotes  from the patent of Farmavita d.o.o. :

• Gummi Boswelli "WHO monographs on selected medicinal plants Volume 4"; World Health Organization, 2009, 
  Summary: Pharmacopoeia Monograph on frankincense.
  
  
• Sontakke S, Thawani V, Pimpalkhute P, Kabra P, Babhulkar S, Hingorani H.: Open, randomized, controlled clinical trial of Boswellia Serrata extract as compared to valdecoxib in osteoarthritis of knee.Indian J Pharmacol 2007;39:27-9.
  Summary: A clinical trial was conducted on 66 persons for a period of 6 months. After two months, in the group that took the Boswellia Serrata extract there were significant improvements recorded in sensations of pain, stiffness and relief related to difficulties in performing daily activities. The improvement was maintained even as far as one month after the group stopped taking the frankincense extract. The group that was taking valdecoxib also showed significant improvement. The improvement occurred after one month of therapy, but it also disappeared more quickly after the therapy was ceased.
  
  
• Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D, Raychaudhuri SP.: A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee.Arthritis Res. Ther. 2008;10(4):R85
  Summary: Clinical trial of frankincense extract (5-Loxin ®) in the treatment of osteoarthritis of the knee was conducted over a period of 90 days. The trial results provide confirmation that the extract of incense is safe to use, and that it significantly reduces the pain and the content of enzymes that break down cartilage (MMP-3).
  
  
•  Ernst E.: Frankincense: systematic review. BMJ 2008; 337:a2813.
  Summary: Summary of results of clinical trials with frankincense extract.
  
  
•  Ichikawa H, Aggarwal BB.: Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.Clin Cancer Res. 2006;12:662–668.
  Summary: Myrrh extract (guggulsterone) is often used to treat osteoarthritis and bone fractures. The results of this in-vitro trial suggest that guggulsterone reduces the formation of large cells (osteoclasts), which play a decisive role in the breakdown of cartilage.
  
  
• Sumantran V N, Kulkarni A, Harsulkar A, Wele A, Koppikar S J, Chandwaskar R, Gaire V, Dalvi M and Wagh U V. Hyaluronidase and collagenase inhibitory activities of the herbal formulation Triphalaguggulu; J. Biosci. 2007, 32(4):755–761
  Summary: "TriphalaGuggulu" is an ayurvedic preparation based on frankincense extract. Results of clinical trials indicate that elevated levels of enzymes hyaluronidase and collagenase significantly affect the degradation of cartilage. The results of this in-vitro trial suggest that TriphalaGuggulu is a potent inhibitor of hyaluronidase and collagenase, thus protecting the chondrocytes.
  
  
• Bio Serae Laboratoires S.A; Results of the Clinical Study Efficiency of a specific formulation containing (Osteol™ + D-Glucosamine + Chondroitin) in reducing knee osteoarthritis symptoms; 2007
  Summary: A mono-centric, randomized, placebo-controlled, double-blind clinical trial was carried out. The trial lasted over a period of 90 days, and it included 57 volunteers who suffered from mild to moderately severe osteoarthritis of the knee. There was no significant difference documented in the total population of trial subjects between the group that took the preparation, and the placebo group. The best result was registered in patients with early-stage osteoarthritis, where the reported reduction in pain was more than 50%. Adverse effects were not observed.
  
  
• Bio Serae Laboratoires S.A.; Prevention of collagen-induced arthritis in mice by a specific formulation with Osteol™; 2008;
  Summary: The results of tests on mice show that the formulation of Osteol ™ with glucosamine and chondroitin reduces the appearance and severity of arthritis. The efficacy of the formulation is comparable to the efficacy of ibuprofen.
  
  
• Bio Serae Laboratoires S.A; Evaluation of the effects of a formulation combining Osteol™ with D-Glucosamine and Chondroitin, on gene expression in culture of chondrocytes in presence of pro-inflammatory cytokines. Analysis of gene expression using dedicated DNA arrays; 2008
  Summary: Results of in-vitro studies have shown that the combination of Osteol ™, glucosamine and chondroitin, under conditions when there is inflammation, helps achieve a significant reduction in expression of genes involved in the preservation of cartilage, and considerably reduces the expression of genes involved in the degradation of cartilage.
  
  
• Bio SeraeLaboratoires S.A; Preservation of Chondrocytes study; 2008
  Summary: Study results indicate that the combination Osteol ™ and D-glucosamine has an anti-inflammatory effect, which is comparable to the effect of ibuprofen.

• Adlerova L, Bartoskova A, Faldyna M.; Lactoferrin: a review Vet Med. 2008, 53 (9): 457-468
  Summary: Overview of the biological properties of lactoferrin.

• Naot, D., Grey, A., Reid, I. R, Cornish, J.; Lactoferrin - A Novel Bone Growth Factor.Clin Med Res 2005, 3 (2): 93-101
  Summary: Lactoferrin is a natural glycoprotein. The study showed that lactoferrin strongly encourages the development and differentiation of cells that are important for formation of bone and cartilage (osteoblasts), and that it has the ability to inhibit the creation of cells that break down bone and cartilage (osteoclasts). Lactoferrin plays an important physiological role in bone growth, and has potential medicinal effects.
  
  
•  Cornish J., et al. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo.Endocrinology. 2004;145(9):4366–4374.
  Summary: The study has found that lactoferrin stimulates the proliferation and differentiation of osteoblasts. Lactoferrin prevents apoptosis of osteoblasts, and stimulates the proliferation of chondrocytes. Lactoferrin potentially inhibits the creation of osteoclasts, but it doesn't inhibit the activity of mature osteoclasts. Lactoferrin accelerates bone growth in-vivo.
  
  
• Zdravko Mauko: Preparation for the treatment of bone disorders and disorders of the joints, Patent P20110080A, Application date: February 04th, 2011.
  Summary: The patent protects the primary right of application related to the invention for treatment of bone disorders and disorders of the joints, specified by consisting of a mixture of dry frankincense resin extract, dried myrrh resin extract and dried lactoferrin extract.